Clinical note

In vasogenic edema,(typically secondary to a brain tumor), the blood vessel are poorly developed, are leaky, and lack the transport properties of a normal BBB. This abnormal vessel permeability results in accumulation of interstitial fluid in the brain. Permeablity of the BBB can also be altered in infections such as bacterial meningitis; although this accounts for some of the adverse neurologic effects of infection, it also permits improved delivery antibiotics to the CNS.